Drosophila melanogaster

Drosophila melanogaster, commonly known as the fruit fly, is a widely studied model organism in genetics and developmental biology. It is known for its role in research due to its relatively simple genetic makeup and short life cycle. D. melanogaster can be a pest of overripe and fermenting fruits, where it lays eggs and the larvae feed on the fruit. Despite its pest status, it has been invaluable in advancing our understanding of genetics and development.

NCBI Taxonomy ID: 7227

18 pairs of Verified P450 and Compounds

Validation

Gene Symbol	Compound	Validation	Reference
CYP12A5	Nitenpyram	R	Evidence for activation of nitenpyram by a mitochondrial cytochrome P450 in Drosophila melanogaster Pest Management Science 2018/6/29 | 10.1002/ps.4852 | WOS:000435094600011 PubMed Link
CYP12D1	Clofenotane	D	Evaluating the insecticide resistance potential of eight Drosophila melanogaster cytochrome P450 genes by transgenic over-expression Insect Biochemistry and Molecular Biology 2007/5/1 | 10.1016/j.ibmb.2007.02.008 | WOS:000246824000012 PubMed Link
CYP12D1	Dicyclanil	D	Evaluating the insecticide resistance potential of eight Drosophila melanogaster cytochrome P450 genes by transgenic over-expression Insect Biochemistry and Molecular Biology 2007/5/1 | 10.1016/j.ibmb.2007.02.008 | WOS:000246824000012 PubMed Link
CYP6A2	Clofenotane	D	Nrf2/Maf-binding-site-containing functional Cyp6a2 allele is associated with DDT resistance in Drosophila melanogaster Pest Management Science 2014/7/16 | 10.1002/ps.3645 | WOS:000337698400006 PubMed Link
CYP6A8	Capric Acid	E	Functional Characterization of Drosophila melanogaster CYP6A8 Fatty Acid Hydroxylase Biomolecules and Therapeutics 2022/8/24 | 10.4062/biomolther.2022.084 | WOS:000838935500001 PubMed Link
CYP6A8	Lauric Acid	Y	Drosophila melanogaster CYP6A8, an insect P450 that catalyzes lauric acid (ω-1)-hydroxylation Biochemical and Biophysical Research Communications 2004/12/24 | 10.1016/j.bbrc.2004.10.194 | WOS:000225557500055 PubMed Link
CYP6A8	Lauric Acid	E	Functional Characterization of Drosophila melanogaster CYP6A8 Fatty Acid Hydroxylase Biomolecules and Therapeutics 2022/8/24 | 10.4062/biomolther.2022.084 | WOS:000838935500001 PubMed Link
CYP6G1	Clofenotane	D	Evaluating the insecticide resistance potential of eight Drosophila melanogaster cytochrome P450 genes by transgenic over-expression Insect Biochemistry and Molecular Biology 2007/5/1 | 10.1016/j.ibmb.2007.02.008 | WOS:000246824000012 PubMed Link
CYP6G1	Clofenotane	X	Metabolism of imidacloprid and DDT by P450 GYP6G1 expressed in cell cultures of Nicotiana tabacum suggests detoxification of these insecticides in Cyp6g1-overexpressing strains of Drosophila melanogaster, leading to resistance Pest Management Science 2008/1/1 | 10.1002/ps.1472 | WOS:000252694100009 PubMed Link
CYP6G1	Clofenotane	R	Dissecting the insecticide-resistance-associated cytochrome P450 gene Cyp6g1 Pest Management Science 2008/6/1 | 10.1002/ps.1567 | WOS:000256639000008 PubMed Link
CYP6G1	Clofenotane	X	Metabolism of Methoxychlor by the P450-Monooxygenase CYP6G1 Involved in Insecticide Resistance of Drosophila melanogaster after Expression in Cell Cultures of Nicotiana tabacum Chemistry and Biodiversity 2010/1/1 | 10.1002/cbdv.200900020 | WOS:000276059600018 PubMed Link
CYP6G1	Nitenpyram	D	Evaluating the insecticide resistance potential of eight Drosophila melanogaster cytochrome P450 genes by transgenic over-expression Insect Biochemistry and Molecular Biology 2007/5/1 | 10.1016/j.ibmb.2007.02.008 | WOS:000246824000012 PubMed Link
CYP6G1	Dicyclanil	D	Evaluating the insecticide resistance potential of eight Drosophila melanogaster cytochrome P450 genes by transgenic over-expression Insect Biochemistry and Molecular Biology 2007/5/1 | 10.1016/j.ibmb.2007.02.008 | WOS:000246824000012 PubMed Link
CYP6G1	Thiamethoxam	X	Eukaryotic expression ofDrosophila CYP6G1 and its metabolism on neonicotinoidinsecticidesinvitro Acta Entomologica Sinica 2023/6/14 | 10.16380/j.kcxb.2023.02.008 | BCI:BCI202300448225
CYP6G1	Imidacloprid	X	Metabolism of imidacloprid and DDT by P450 GYP6G1 expressed in cell cultures of Nicotiana tabacum suggests detoxification of these insecticides in Cyp6g1-overexpressing strains of Drosophila melanogaster, leading to resistance Pest Management Science 2008/1/1 | 10.1002/ps.1472 | WOS:000252694100009 PubMed Link
CYP6G1	Imidacloprid	R	Insecticide detoxification indicator strains as tools for enhancing chemical discovery screens Pest Management Science 2012/2/16 | 10.1002/ps.2218 | WOS:000298589800006 PubMed Link
CYP6G2	Diazinon	D	Evaluating the insecticide resistance potential of eight Drosophila melanogaster cytochrome P450 genes by transgenic over-expression Insect Biochemistry and Molecular Biology 2007/5/1 | 10.1016/j.ibmb.2007.02.008 | WOS:000246824000012 PubMed Link
CYP6G2	Nitenpyram	D	Evaluating the insecticide resistance potential of eight Drosophila melanogaster cytochrome P450 genes by transgenic over-expression Insect Biochemistry and Molecular Biology 2007/5/1 | 10.1016/j.ibmb.2007.02.008 | WOS:000246824000012 PubMed Link