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Insect-eP450DB
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Insecta
Diptera
Culicidae
Anopheles
CYP6P9B
Oganism
Anopheles funestus
NCBI Accession
Gene | 125764713
3D Structure
Download
Nucleotide
Protein
3D Structure
14
pairs of Verified P450 and Compound
Validation
Compound
Validation
Reference
Coumarin
X
Biochemical profiling of functionally expressed CYP6P9 variants of the malaria vector Anopheles funestus with special reference to cytochrome b5 and its role in pyrethroid and coumarin substrate metabolism
Pesticide Biochemistry and Physiology
2022/3/22 | 10.1016/j.pestbp.2022.105051 | WOS:000765514700004
PubMed Link
Bendiocarb
E
Functional Validation of Endogenous Redox Partner Cytochrome P450 Reductase Reveals the Key P450s CYP6P9a/-b as Broad Substrate Metabolizers Conferring Cross-Resistance to Different Insecticide Classes in Anopheles funestus
International Journal of Molecular Sciences
2024/8/16 | 10.3390/ijms25158092 | WOS:001288945100001
PubMed Link
Cypermethrin
E
Functional Validation of Endogenous Redox Partner Cytochrome P450 Reductase Reveals the Key P450s CYP6P9a/-b as Broad Substrate Metabolizers Conferring Cross-Resistance to Different Insecticide Classes in Anopheles funestus
International Journal of Molecular Sciences
2024/8/16 | 10.3390/ijms25158092 | WOS:001288945100001
PubMed Link
Clofenotane
E
Functional Validation of Endogenous Redox Partner Cytochrome P450 Reductase Reveals the Key P450s CYP6P9a/-b as Broad Substrate Metabolizers Conferring Cross-Resistance to Different Insecticide Classes in Anopheles funestus
International Journal of Molecular Sciences
2024/8/16 | 10.3390/ijms25158092 | WOS:001288945100001
PubMed Link
Permethrin
D,E
Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus
Proceedings of The National Academy of Sciences of The United States of America
2013/1/2 | 10.1073/pnas.1216705110 | WOS:000313630300059
PubMed Link
Permethrin
D
Allelic Variation of Cytochrome P450s Drives Resistance to Bednet Insecticides in a Major Malaria Vector
Plos Genetics
2015/12/2 | 10.1371/journal.pgen.1005618 | WOS:000364401600077
PubMed Link
Deltamethrin
D,E
Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus
Proceedings of The National Academy of Sciences of The United States of America
2013/1/2 | 10.1073/pnas.1216705110 | WOS:000313630300059
PubMed Link
Deltamethrin
D
Allelic Variation of Cytochrome P450s Drives Resistance to Bednet Insecticides in a Major Malaria Vector
Plos Genetics
2015/12/2 | 10.1371/journal.pgen.1005618 | WOS:000364401600077
PubMed Link
Chlorfenapyr
E
Functional Validation of Endogenous Redox Partner Cytochrome P450 Reductase Reveals the Key P450s CYP6P9a/-b as Broad Substrate Metabolizers Conferring Cross-Resistance to Different Insecticide Classes in Anopheles funestus
International Journal of Molecular Sciences
2024/8/16 | 10.3390/ijms25158092 | WOS:001288945100001
PubMed Link
Chlorfenapyr
R,D
Substrate promiscuity of key resistance P450s confers clothianidin resistance while increasing chlorfenapyr potency in malaria vectors
Cell Reports
2024/8/22 | 10.1016/j.celrep.2024.114566 | WOS:001292703700001
PubMed Link
lambda-CYHALOTHRIN
D,E
Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus
Proceedings of The National Academy of Sciences of The United States of America
2013/1/2 | 10.1073/pnas.1216705110 | WOS:000313630300059
PubMed Link
Bifenthrin
D,E
Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus
Proceedings of The National Academy of Sciences of The United States of America
2013/1/2 | 10.1073/pnas.1216705110 | WOS:000313630300059
PubMed Link
Clothianidin
E
Functional Validation of Endogenous Redox Partner Cytochrome P450 Reductase Reveals the Key P450s CYP6P9a/-b as Broad Substrate Metabolizers Conferring Cross-Resistance to Different Insecticide Classes in Anopheles funestus
International Journal of Molecular Sciences
2024/8/16 | 10.3390/ijms25158092 | WOS:001288945100001
PubMed Link
Clothianidin
R,D
Substrate promiscuity of key resistance P450s confers clothianidin resistance while increasing chlorfenapyr potency in malaria vectors
Cell Reports
2024/8/22 | 10.1016/j.celrep.2024.114566 | WOS:001292703700001
PubMed Link